izvorni znanstveni rad
Amlodipine, 3-ethyl 5-methyl-2-[(2-aminoethoxymethyl]-4-(2-chlorophenyl)-1, 4-dihydro-6-methy l-3, 5-pyridinedicarboxylate, is a chiral calcium antagonist, currently on the market and in therapeutic use as a racemate. The pharmacokinetic behaviour of R-(+)- and S-(-)-amlodipine after single enantiomer administration to healthy male human volunteers together with comparative administration of the racemic mixture of both enantiomers were studied. Plasma levels were studied as a function of time and assayed using an enantioselective chromatographic method (coupled chiral and achiral HPLC) with on-line solid-phase extraction and UV absorbance detection. The method was validated separately for the R-(+)- and S-(-)-enantiomer, respectively. Results of the study indicate that the pharmacokinetic behaviour of R-(+)- and S-(-)-amlodipine after single enantiomer administration is comparable to that of each enantiomer after administration of the racemate. No racemization occurs in vivo in human plasma after single enantiomer administration.
Enantiomer separation; Amlodipine
Razvojem virtualizacijskih tehnologija raste kompleksnost IT sustava, dok korisnici istovremeno zahtijevaju brži pristup resursima, napredne integracije i jednostavnost korištenja. Jedno od ključnih rješenja za ove izazove primjena je…
Ovaj rad istražuje i uspoređuje mogućnosti prosljeđivanja grafičkih kartica na Hyper-V i KVM hipervizorima prema virtualnim strojevima, detaljno opisujući metode, postupke i razlike u arhitekturi koje utječu na…
The ever-growing usage and adaptation of HTTP/3 in web traffic leverages Quick UDP Internet Connections (QUIC) as a transport protocol. QUIC is widely recognized for reduced latency, enhanced…
