Nanoindentation characterization of synthetic pelvic prolapse mesh materials

Pelvic organs prolapse (POP) is a common condition that affects a significant proportion of women worldwide, and surgical mesh implantation has emerged as a viable treatment option. However, the biomechanical properties of different mesh materials may vary and can influence their long- term clinical outcomes. Therefore, this study aims to evaluate the mechanical properties of various commercially available POP meshes using nanoindentation. Nanoindentation is a reliable and accurate method to determine the mechanical characteristics of small materials at the nanoscale level. Several mechanical properties, including hardness, elastic modulus, and viscoelastic properties, will be investigated. The findings of this study will provide essential information on the mechanical behavior of different POP meshes and assist clinicians in selecting the most suitable mesh for their patients. Ultimately, this research could improve the long-term efficacy and safety of surgical mesh implants for treating POP, reducing the burden of this debilitating condition for women worldwide.