Tehničko veleučilište u Zagrebu · Zagreb

Electrospinning of PCL/CEFUROXIM® fibrous scaffolds on 3D printed collectors

izvorni znanstveni rad

izvorni znanstveni rad

Electrospinning of PCL/CEFUROXIM® fibrous scaffolds on 3D printed collectors

Vrsta prilog u časopisu
Tip izvorni znanstveni rad
Godina 2020
Časopis Journal of the Textile Institute
Nadređena publikacija Journal of the textile institute
Volumen 111
Svesčić 9
Stranice str. 1288-1299
DOI 10.1080/00405000.2019.1707347
ISSN 0040-5000
EISSN 1754-2340
Status objavljeno

Sažetak

In this paper, the effect of different collector geometry on the PCL scaffold architecture and cell viability was investigated. PCL scaffolds with antibiotic CefuroximVR , 15%wt. and 20%wt., were electrospun and characterized by ATR-FTIR, while thermal stability were observed by DSC and TG. PCL/15%CFUVR scaffolds were electrospun on six 3D printed collectors, three ribbed and three mesh geometries, to produce the most favourable structure for cells adhesion and proliferation. SEM study and MTT assay revealed that collectors with the widest slot in both ribbed and mesh geometries exhibited the most favourable structure to enhance cells adhesion. In general, cells spreading on the surface and cells viability proved to be better for the ribbed collectors. The study showed that by controlling the collector geometry and the scaffold three-dimensional structure, it is possible to control cell attachment and differentiation and, consequently, to adjust them for the special tissue demands in the regeneration process.

Ključne riječi

Electrospinning ; PCL ; Cefuroxim® ; 3D printing ; thermal analysis ; scaffolds